May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation. Stimulates transcription activity of the RNA polymerase I complex. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. SIRT7 thereby acts as a transcription repressor. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). SIR2L7 NAD-dependent protein deacetylase sirtuin-7 Regulatory protein SIR2 homolog 7 SIR2-like protein 7 SIRT7 Aliquot into multiple vials to avoid repeated freeze-thaw cycles. KLH conjugated synthetic peptide derived from human SIRT7Īqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Working load - a load that can be safely carried by a structural member.SIRT7 Polyclonal Antibody, C圓 Conjugated Transom - a scaffold tube spanning across ledgers and supporting scaffold boards forming a working platform or connecting outer standards to inner standards. Swivel coupler - a coupler for joining tubes at an angle (i.e. Scaffold tube - any tubular element of a scaffold: standard, ledger, transom etc. These chemical-resistant racks have molded letters and numbers for easy identification. Safe working moment - is a characteristic moment of resistance divided by a factor of safety. Catalog number: 5973-0015PK Related applications: Lab Clean Up, Safety & Organization Technical Support Customer Service Save lab space with stackable Thermo Scientific Nalgene Microcentrifuge Tube Racks. Rests in or on part of a brickwork structure. Putlog - a scaffold tube with flattened end. Supports putlogs or transoms, and frequently for ties and ledger braces. Ledger - a longitudinal scaffold tube (normally) parallel to a building face. Can be temporary or permanent.īase Plate - a rigid plate under a standard, used to spread reaction.īay - space between two adjacent standards along face of a scaffold.īay Length - distance between centres of two adjacent standards.Ĭoupler - an element that connects two scaffold tubes together.
Anchor - an element that transfers forces between a scaffolding tie and a supporting structure.
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